Curcumin therapy prevents ethanol-induced fatty liver disease

Researchers from Longyan University and the University of Science and Technology of China report that curcumin has protective effects against alcoholic fatty liver disease. In their study, which appeared in Toxicology and Applied Pharmacology, the team carried out a metabolomic analysis to determine the effects of alcohol consumption and curcumin on mice liver.

  • Curcumin has been known to possess powerful antioxidant and anti-inflammatory properties. However, its effect on fat metabolism in the liver has not been fully understood.
  • For the study, the researchers induced alcoholic fatty liver in mice using ethanol.
  • Ethanol increased stored fat in the liver, resulting in alcoholic fatty liver disease.
  • However, the results showed that curcumin treatment suppressed ethanol-induced impairment in lipid metabolism.
  • These suggest that curcumin has the ability to inhibit fatty acid biosynthesis.

Based on these findings, curcumin can improve alcoholic fatty liver by suppressing fatty acid biosynthesis.


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Journal Reference:

Guo C, Ma J, Zhong Q, Zhao M, Hu T, Chen T, Qiu L, Wen L. CURCUMIN IMPROVES ALCOHOLIC FATTY LIVER BY INHIBITING FATTY ACID BIOSYNTHESIS. Toxicology and Applied Pharmacology. 01 August 2017;328:1-9. DOI: 10.1016/j.taap.2017.05.001

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